The objectives of the present study were to assess the association of differing EMT phenotypes in systemic cancer cells of MBC with their ability to form lung metastases in vitro, ex vivo, and in vivo in the 4T1 MBC syngeneic mouse model. Our major focus was on CTCs and DTCs, their EMT phenotypes, proliferation, adhesion, migration, invasion, tumorigenesis, and metastatic potential. In addition, the objective of the study was to analyze EMT phenotypes of systemic CTCs and DTCs from primary patients with MBC and to correlate EMT phenotypes with the metastatic status and clinical outcome of the patients.

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