Genotyping data from the CV samples (table S10) were obtained using the Illumina Infinium PsychArray Bead-Chip platform. SCZ risk SNPs related to calcium signaling were selected for analysis based on previous reports (7) and included variants in the ATP2A2 (rs4766428), CACNA1C (rs2159100, rs2007044, and rs758117), CACNB2 (rs7893279), CACNA1I (rs5757730), CALN1 (rs2944823), NLGN4X (rs12845396), RIMS1 (rs1339227), and TMEM110 (rs2535627) genes. For SNPs not included in the Illumina Infinium PsychArray Bead-Chip array (rs758117, rs7893279, rs12845396, and rs1339227), we used the LDproxy tool of LDlink (60) and the 1000 Genomes European population as a reference to identify measured SNPs that were in the highest linkage disequilibrium (R2 > 0.8) with the SNPs of interest (rs10491964, R2 = 0.93; rs4748466, R2 = 0.85; rs12835663, R2 = 0.83; and rs2789588, R2 = 0.82, respectively) and analyzed them as a proxy. Association between response to thapsigargin at PLC-γ1, expressed as the EC50, and the number of SCZ risk alleles per individual was assessed using fixed-effects linear regression (one-tailed test; H0, β ≤ 0; H1, β > 0) adjusted for age, gender, and body mass index (BMI). P values were obtained by permutation testing (n = 1000 permutations).

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