We performed statistical analysis using GraphPad Prism 6 (GraphPad Software Inc.). We also used this software to perform t tests to determine significance. Replicates are indicated throughout the figure captions. All graphical data are reported as means ± SD. Significance levels were set at *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. All graphical data were reported.

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