We used a combined cohort of breast cancer patient data with endocrine therapy in Kaplan-Meier plotter (http://kmplot.com/) for the survival analysis. The data and method used for the analysis were described previously (47). Briefly, patients are stratified into high- or low-expression groups according to the median level of individual gene probe. The survival analysis was performed using the survival package in the R statistical environment. Proportional hazard was computed using the coxph package.

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