ChIP-seq was performed as previously described (41). For ChIP-seq analysis, TET2 peaks in both TET2-WT and TET2-KO or shNONT and shTET2 conditions were called with the MACS v1.4.2 software (42) using default parameters and corresponding input samples. Metaplots and heat maps were generated using ngsplot (43). The GREAT online software suite was used to analyze cis-regulatory function for select clusters (44).

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