Mice. All breeding and experiments were undertaken with review and approval from the Animal Ethical and Experimental Committee of Third Military Medical University (table S2). Through material transfer agreements, C57BL/6 MMP-10−/− mice were obtained from W. C. Parks (University of Washington, USA), and C57BL/6 IL-22−/− mice were obtained from W. Ouyang (Genentech). IL-22−/−MMP-10−/− mice and their littermate control (WT) mice were generated by cross-breeding with IL-22−/− and MMP-10−/− mice. C57BL/6 IL-17A−/− mice and C57BL/6 IFN-γ−/− mice were provided by R. A. Flavell (Yale University, USA). C57BL/6Rag1−/− and C57BL/6CD8−/− mice were obtained from the Jackson Laboratory (Bar Harbor, USA). All mice used in experiments were female except male mice for chimeric experiments and were viral Ab free for pathogenic murine viruses, negative for pathogenic bacteria including Helicobacter spp. and parasites, and were maintained under specific pathogen-free conditions in a barrier-sustained facility and provided with sterile food and water (8).

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