Full three-dimensional (3D) FEA was used to study the mechanical performance of the devices, which were mounted on phantom skin (Ecoflex, 60kPa, 60 by 60 by 2.5 mm) and subjected to stretching, bending, and twisting. For stretching, displacements corresponding to 30% stretching were applied to two ends of the skin, which resulted in an ~20% average tensile stretch on the bottom surface of the device along the stretching direction. For twisting, the two ends of the skin are twisted by 67.5° relatively. For bending, the bottom surface of the phantom skin was pressed to a rigid cylinder of 3-cm radius. Eight-node 3D solid elements were used for SIS microfluidic channels, adhesive layer, and phantom skin.

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