All cell culture experiments were realized at least by three independent experiments, and for one experiment, each condition was performed in triplicate. In vivo analyses were conducted with at least three animals per condition. The exact number of experiments is indicated in the figures or in the legends. Values are given as mean with SD. Normality of the data was checked with the F test. The unpaired Student’s t test was used to generate P values for selected pairwise comparisons, and P < 0.05 was considered significant.

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