Since the demonstration that indomethacin reduces inflammation caused by intraplantar injection of λ-carrageenan, this acute model is widely accepted for screening compounds with anti-inflammatory potentialities (38). λ-Carrageenan was dissolved in physiological saline (NaCl, 0.9%) just before injection. Rats or mice received a single intraplantar injection of λ-carrageenan solution in the plantar region of the right hind paw (23, 39) to induce inflammation. The injected λ-carrageenan dose corresponded to 100 μl (2% solution, w/v) for rat and 20 μl (3% solution, w/v) for mice. Inflammation reached its maximum 3 hours after λ-carrageenan injection. Thermal nociceptive test was then performed on the ipsilateral inflamed hind paw.

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