Pathway enrichment and GO analysis were conducted using WebGestalt (31) v. 2017. Kyoto Encyclopedia of Genes and Genomes (KEGG) was used as the functional database where the list of expressed genes, with fragments per kilobase of transcript per million (FPKM) >1, was used as the background. The maximum and minimum number of genes for each category were set to 2000 and 5, respectively, based on the default setting. Bonferroni-Hochberg multiple test adjustment was applied to the enrichment output. FDR significance threshold was set to 0.05.

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