Data are presented as means ± SEM unless indicated otherwise. All histograms display individual points, which represent the values and number of individual samples for each condition. Data distributions were tested for normality, and variance equality between groups was assessed using the Levene’s test. Statistical comparisons were performed using unpaired Student’s t tests and one-way ANOVA or two-way repeated-measures ANOVA. For post hoc analysis, we used Bonferroni’s correction for multiple comparisons. Statistical analysis was performed with IBM SPSS Statistics 19 (SPSS), and P < 0.05 was considered statistically significant. Significance is mainly displayed as *P < 0.05, **P < 0.01, and ***P < 0.001, and in some cases is indicated as #P < 0.05, ##P < 0.01, and ###P < 0.001 for multiple comparisons (not significant values are not denoted).

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