Homology models of AIM and IgM-Fc were generated using the SWISS-MODEL server (http://swissmodel.expasy.org/). Templates with the highest quality (5a2e.1.A and 1o0v.1.B for AIM and IgM-Fc, respectively) were selected for model building. Models were built on the basis of target-template alignment and subjected to energy minimization using PRIME (Schrödinger LLC, New York, NY). Molecular graphics images were produced using the PyMOL (Schrödinger Inc., MA, USA). Colors indicate the following: Blue is positively charged, red is negatively charged, and white is neutrally charged.

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