The Cdh5-CreERT2 PAC transgenic mice (iECre), and Ccm1fl/fl and Ccm2fl/fl animals have been previously described (7, 30, 31). All experimental animals were maintained on a C57BL/6J genetic background. The Sydney Local Health District Animal Welfare Committee and Institutional Animal Care and Use Committee of Tianjin Medical University approved all animal ethics and protocols. All experiments were conducted under the guidelines/regulations of Centenary Institute, The University of Sydney, and Tianjin Medical University.

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