Statistical analysis was performed using SPSS and R software. P < 0.05 indicates significance. The survival curves were constructed according to the Kaplan-Meier method and compared with the log-rank test. Relapse-free survival was assessed from the date of surgery to the date of local relapse or distant relapse. Overall survival was assessed from the date of surgery to the date of death or last follow-up. Patients without events or death were censored at the last follow-up.

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