Male Kunming mice (25 to 30 g) and female Balb/c mice were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences. The animal experiments were performed according to the NIH Guide for the Care and Use of Laboratory Animals (National Institutes of Health Publication, No. 3040-2, revised 1999, Bethesda, MD) and were approved by the Animal Care and Use Committee of the Chinese Academy of Sciences.

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