All human blood and tissue samples were collected and analyzed with approved protocols in accordance with the ethical requirements and regulations of the Oregon Health & Science University (OHSU) institutional review board. Informed consent was obtained from all subjects. Peripheral blood was obtained from cancer patients diagnosed with PDAC at various stages and treated at OHSU, as well as from healthy controls. Identification and acquisition of solid tumor or peripheral blood biopsies from female patients who previously received a gender-mismatched bone marrow transplantation was conducted by screening of the Center for International Bone Marrow Transplant Registry.

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