Statistical calculations were performed using IBM SPSS statistics 23. Categorical data were described and analyzed by frequency and χ2 test. For parametric comparison, two-tailed Mann-Whitney U test was used to assess differences between groups during p-cofilin profiling (Fig. 2). Spearman rank correlation tests were used to measure the correlations between variables. Unless otherwise stated, a P value less than 0.05 was considered statistically significant.

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