Patients were scanned in anesthesia after medical decision, with the aim of minimizing motion in the scanner, and it was performed by a certified anesthesiologist. Before scanning, all patients fasted for at least 6 hours for solids and 2 hours for liquids. Propofol was administered through intravenous infusion using a target-controlled infusion system, and the concentration was kept to the minimum (1 to 2 μg/ml). To ensure adequate airing, some patients received assisted mechanical ventilation through a tracheostomy, a laryngeal mask, or an endotracheal tube when already in place. Additional oxygen was delivered in some cases, either through a face mask or through the airway instrumentation device. Patients’ physiologic parameters (arterial blood pressure, electrocardiogram, breathing frequency, and pulse oximetry) were closely and continuously monitored. Propofol was titrated to achieve immobility in the scanner. Once obtained, the necessary plasma concentration of propofol was kept constant throughout the procedure. A complete resuscitation equipment was present during the procedure.

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