APP:PS1 double transgenic mice were purchased from the Jackson Laboratories. These mice overexpressed mutant human amyloid precursor protein gene containing the Swedish mutation K594N/M595L and the delta E9 mutant human presenilin 1 gene under the control of the prion promoter. Their AD neuropathology is well characterized, with plaque deposition starting at 5 months of age (52, 53).

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