All animal experiments were performed in the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC)–accredited animal housing facilities at the National Health Research Institutes (NHRI). All mice were used according to the protocols and guidelines approved by the Institutional Animal Care and Use Committee of NHRI. Floxed AhR mice (JAX 006203), IL-17A–deficient mice (JAX 016879), floxed RORγt mice (JAX 008771), and floxed IKKβ mice (EMMA 001921) were purchased from the Jackson Laboratory (JAX) or the European Mouse Mutant Archive (EMMA). The three aforementioned mouse lines were backcrossed for 10 generations onto the C57BL/6 background. The data presented in this study were performed on sex-matched, 4- to 26-week-old littermates. For T cell development analyses, 5-week-old, sex-matched mice were used. All mice used in this study were maintained in temperature-controlled and pathogen-free cages.

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