All depth-resolved data were interpolated (interp2, MATLAB R2016a) for visualization. The average amount of copepodamides in the water column over time was calculated by averaging columns of the interpolated copepodamide concentration matrix. The predicted level of induction was calculated from dose-response relationships and the average copepodamide concentration in the upper 15 m at the study site. Only intact copepodamides were used, as deacylated copepodamides G and H are inactive at ecologically relevant concentrations [fig. S4; (14)]. To be conservative, we doubled the average concentration used to calculate dose-response relationships for this purpose. The dose-response curve fits were performed in MATLAB R2016a based on the Michaelis-Menten equation.

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