We exposed Skeletonema and Pseudo-nitzschia to copepodamides purified from C. finmarchicus, as described in (14). At the same time, we measured copepodamides in situ off the Swedish west coast biweekly for 1 year. The dose-response relationships for Skeletonema and Pseudo-nitzschia were combined to predict the level of induction in nature. Sample sizes and duration of experiments were derived from effect size and variance estimates in pilot experiments.

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