C57BL/6J and BALB/c WT mice were obtained from Janvier. CCSP-rtTA × tet-O–VEGF-C mice (22, 23) were backcrossed into the C57BL/6 and BALB/c backgrounds. Prox1-GFP mice were provided by Y.-K. Hong, University of Southern California (29). All mice were housed under specific pathogen–free conditions. The overexpression of VEGF-C in CCSP-rtTA × tet-O–VEGF-C mice was induced by administration of doxycycline (1 mg/ml, C57BL/6 mice; 2 mg/ml, BALB/c mice) in drinking water (containing 5% sucrose) for 2 weeks, starting at 8 weeks of age.

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