We selected papers that reported neurosyphilis diagnostic methods and strategies for patients with Treponema pallidum infection, regardless of the clinical presentation, that assessed their performance in comparison with a gold standard. We included only observational and diagnostic test studies. Clinical trials, reviews, case reports, research protocols, and presentations at conferences were not considered.

We excluded papers that were unpublished, inaccessible, or incomplete. If the article did not present a diagnostic method and its performance, it was also excluded from this review.

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