Our primary outcome is neurological function (neurobehavioral performance). Some examples of neurobehavioral tests that we expect to encounter include, but are not limited to, cylinder test, beam balance, beam walking, rotarod test, open field test, Morris water maze, elevated T-maze, and passive avoidance. Our secondary outcomes include mortality, infarct size, intracranial pressure, cerebral perfusion pressure, cerebral blood flow, and brain tissue oxygen tension. We will consider all neurobehavioral tests reported in the included studies. We will collect information on the definition of mortality used in included studies, whether animals had died spontaneously or if they received euthanasia when they reached a state of imminent death according to specific criteria of deterioration of their condition.

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