This protocol is based on The Cochrane Handbook for Systematic Reviews of Interventions and specific recommendations for conducting systematic reviews and meta-analysis of preclinical studies [25, 26]. We will report our results according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) [27]. The present protocol has been registered within the PROSPERO database (registration number CRD42018086662) and is being reported in accordance with the reporting guidance provided in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement [28, 29] (see checklist in Additional file 1).

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