During title and abstract screening, articles were included if they evaluated at least one biomarker or clinical scoring system in any infectious disease. During full text screening, articles were included if they evaluated at least one biomarker combined with another biomarker or clinical scoring system and reported the prognostic accuracy on 28 or 30 day mortality by AUC in patients with sepsis. Other measurements of the studied prediction models were recorded, such as sensitivity, specificity and Hosmer-Lemeshow test statistic, if they were reported by the authors. However, articles were not excluded if these values were missing.

Studies in children and studies of which the full text was not available in English were excluded.

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