Figure Figure11 displays an overview of the study design and participant flow through the trial. Once a participant is eligible to join the study, he or she will be asked to provide additional information during the 60-min on-site eligibility screening session, including basic socio-demographic information (e.g., sex and gender), medical history (cardiovascular, respiratory, neurological), lifestyle habits (e.g., smoking history, physical activity levels), descriptive physical data (e.g., height, weight), level of education, current and past income and occupation, and current medications (prescribed, over-the-counter, and vitamins or supplements).

Overview of study design and participant flow through the trial

After the completion of the screening procedures, the participants will be randomly assigned to one of the four experimental groups. Following randomization, participants will undergo their first set of cerebrovascular/physiological, neuroimaging, sleep, and cognitive factors and will complete several lifestyle and psychological questionnaires (see Table Table2).2). This battery of assessments will be completed again following the 6-month intervention period and after a 1-year follow-up period.

Schedule of physiological, cognitive, psychological, and neuroimaging assessments for the Brain in Motion II trial

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