Risks of exercise include falls, musculoskeletal injuries, coronary heart disease events (myocardial infarct, acute coronary syndrome), and other side effects that are generally minor. Our previous experience with similar exercise interventions gives our team considerable expertise on the means to mitigate these types of health risks. Maximal cardiopulmonary testing will be conducted by certified exercise physiologists with a physician on-call and present for high-risk participants and appropriate emergency equipment available. A participant may be withdrawn from the study if a research procedure is judged to be potentially harmful or presents an unacceptable risk of injury to the participant. For example, participants could be withdrawn if they develop an abnormality (e.g., abnormal ECG suggesting an unstable cardiac issue, uncontrolled hypertension) that is judged by a physician associated with the study or the participant’s attending physician to pose a risk to the participant if they continue in the study.

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