The data on all the patients identified were gathered from the registers of the nationwide database SIA/SUS. The files that make up the database are fragmented by state, year, and month. The records were linked by the National Health Card number for follow-up using deterministic linkage. There was no linkage with another database.

The first date of SGA provision identified in the SIA/SUS database during the period from January 1, 2008, to December 31, 2017, was considered as the cohort entry date. Some patients might already have received SGAs when they entered the cohort.

During the 10-year study period, all patients were followed up until the last patient record in the SIA/SUS or death. Our analysis did not exclude or censor any patient during the period of study.

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