Fisher's exact test was used to compare categorical variables. Multivariate logistic regression analysis was performed to assess the relationship between dose reduction of afatinib and sex, age, sarcopenia, BSA and BMI. PFS was estimated using the Kaplan–Meier method and compared using the log‐rank test. A two‐tailed p‐value of less than 0.05 was considered to be statistically significant. Statistical analysis was performed using SPSS software, version 22.0 (IBM Corp). This study was approved by the institutional review boards of Beijing Hospital.

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