IBM SPSS Statistics for Windows, version 22.0 (IBM Corp.) was used for the statistical analysis. Student's t-test (paired or unpaired depending on the data) was used for the analysis of continuous variables (mean ± standard deviation). One-way analysis of variance with Tukey's post hoc test was used to evaluate the differences between multiple groups. Associations among pathological features (categorical variables) were evaluated using the χ2 and Fisher's exact tests. Correlations were assessed using the Pearson correlation coefficient. P<0.05 was considered to indicate a statistically significant difference.

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