A total of 63 CRC tissues and their corresponding adjacent non-cancer tissues were collected from January 2017 to December 2018 in the Department of Pathology of the First Affiliated Hospital of Hainan Medical University (Haikou, China). All patients (age, 28–86 years; mean age, 58.3 years) included in the study had undergone surgical resection but without previous surgery, radiotherapy or chemotherapy. All cases were diagnosed pathologically by two senior pathologists. Clinicopathological characteristics, such as age, sex, tumor size and tumor TNM stage according to the AJCC 8th Edition (19), were obtained from electronic medical records and are summarized in Table I. To maintain the consistency of the biological information, three pairs of cases with similar clinical data were selected for miRNA microarray analysis (Table SI and Fig. S1). All the patients provided written consent for their specimens to be used in the study. The study was approved by the Ethics Committee of the First Affiliated Hospital of Hainan Medical University.

Association between miR-142-3p expression and pathological characteristics of patients with colon cancer.

miR, microRNA; TNM, Tumor-Node-Metastasis.

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