Twenty 4-week-old BALB/Cnu/nu nude mice (20 g) were purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd. and housed in a pathogen-free environment. All experimental protocols were approved by the Institutional Committee for Animal Care and Use at Shenzhen University. All animal work was performed in accordance with the approved protocol.

The protocol for collecting patient samples was approved by Shenzhen University. Written consent was obtained from every patient attending this study. All work was performed in accordance with the approved protocol.

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