The rats were randomly assigned to five groups (n = 6/group): normal control (NC), diabetic control (DC), diabetic + 300 mg/kg b.w./day of MP (D+MP), diabetic + 300 mg/kg b.w./day of metformin (D + Met) and diabetic + MP + Met (D + MP + Met). The doses for MP and metformin were as used in our previous study [5]. The rats were treated for 4 weeks, after which they were sacrificed under pentobarbital (60 mg/kg b.w.) anesthesia after an overnight fast.

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