To test the storage stability of the icaritin-loaded micelles (IPMs), the freshly prepared IPMs were transferred into glass vials, and stored at 4 °C and 25 °C for 1, 2, 4, and 8 weeks. The particle size and polydispersity index (PDI) and LC were measured at predetermined time points, as described earlier.

The stability of the IPMs in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was also assessed based on the changes in the particle size and the PDI and LC of the micelles over time during their incubation in SGF and SIF, under shaking at a speed of 100 rpm at 37 °C. The particle size and PDI, and LC were determined at 1, 2, 4, 6, and 12 h, as described earlier.

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