The skin permeation results of betulin and its derivative and the accumulation of these compounds in the skin are presented as the mean ± standard deviation (SD). Statistical calculations were made using Statistica 13 PL software (StatSoft, Polska) and the Tukey post-hoc test. The results were evaluated using a one-way analysis of variance (ANOVA). Probabilities p < 0.05 were considered statistically significant.

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