The quality and risk of bias were evaluated independently by two authors (S.J.; B.M.) applying the ROBINS-I tool [22], which was founded for “assessing risk of bias in a non-randomized study”. The following issues were evaluated: (a) confounding factors, (b) selection of participants, (c) classification of interventions, (d) deviations from intended interventions, (e) missing data, (f) outcome measurements and (g) selection of reported result (see Section 3.5). Criteria were categorized as “low risk,” “moderate risk,” “serious risk”, “critical risk” of bias or “no information”, respectively, and rating was resolved by discussion in case of any disagreement.

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