Neuroscience

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    Characterizing Hedonic Responses to Flavors Paired with Internal Pain and Nausea through the Taste Reactivity Test in Rats
    Authors:  Matías López, Dominic M. Dwyer, Patricia Gasalla, Claudia Jove and Azucena Begega, date: 09/20/2022, view: 826, Q&A: 0

    Feeding behavior is a complex experience that involves not only sensory (i.e., visual, odor, taste, or texture) but also affective or emotional aspects (i.e., pleasure, palatability, or hedonic value) of foods. As such, behavioral tests that assess

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    Aerotaxis Assay in Caenorhabditis elegans to Study Behavioral Plasticity
    Authors:  Qiaochu Li, Daniel-Cosmin Marcu, Paul H. Dear and Karl Emanuel Busch, date: 08/20/2022, view: 966, Q&A: 0

    C. elegans shows robust and reproducible behavioral responses to oxygen. Specifically, worms prefer O2 levels of 5–10% and avoid too high or too low O2. Their O2 preference is not fixed but shows plasticity depending on experience, context, or

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    Protocol to Study Spatial Subgoal Learning Using Escape Behavior in Mice
    Authors:  Philip Shamash and Tiago Branco, date: 06/20/2022, view: 1246, Q&A: 0

    Rodent spatial navigation is a key model system for studying mammalian cognition and its neural mechanisms. Of particular interest is how animals memorize the structure of their environments and compute multi-step routes to a goal. Previous work on

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    Time-off-pick Assay to Measure Caenorhabditis elegans Motility
    Authors:  Alyssa C. Walker, Rohan Bhargava, Amanda S. Brust, Ali A. Owji and Daniel M. Czyż, date: 06/20/2022, view: 1588, Q&A: 0

    Caenorhabditis elegans is a simple metazoan that is often used as a model organism to study various human ailments with impaired motility phenotypes, including protein conformational diseases. Numerous motility assays that measure neuro-muscular

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    Self-Paced Five-Choice Serial Reaction Time-Task for Mouse Behavioral Testing
    Authors:  Julie Cunningham, Leah Dinah Sheppard, Eduardo Listik and Qin Wang, date: 04/20/2022, view: 781, Q&A: 0

    The five-choice serial reaction time-task (5-CSRTT) is a behavioral rodent test that can assess executive functioning. It may be employed to analyze distinctive aspects of murine models for a plethora of diseases, such as attention deficit

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    Anticipatory and Consummatory Responses to Touch and Food Rewards: A Protocol for Human Research
    Authors:  Emilio Chiappini, Giorgia Silani and Sebastian Korb, date: 02/20/2022, view: 1068, Q&A: 0

    Understanding the neural basis of reward processing is a major concern, as it holds the key to alleviating symptoms of addiction and poor mental health. However, this goal seems difficult to attain as long as research on reward processing cannot

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    A Behavioural Assay to Investigate Judgment Bias in Zebrafish
    Authors:  Felipe Espigares, Raquel R. Martins and Rui F. Oliveira, date: 02/20/2022, view: 1458, Q&A: 1

    In this protocol, we describe for the first time a judgment bias paradigm to phenotype the way zebrafish assess ambiguous stimuli. We have developed and validated a protocol for a judgment bias test based on a Go/No-go task, and performed using a

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    Induction of Repeated Social Defeat Stress in Rats
    Authors:  Soumyabrata Munshi, Alexandra Ritger and J. Amiel Rosenkranz, date: 02/05/2022, view: 1322, Q&A: 0

    Repeated social defeat stress (RSDS) is a model of chronic stress in rodents. There are several variants of social defeat procedures that exert robust effects in mice, but few published detailed protocols to produce a robust stress and altered

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    Protocols to Induce, Prevent, and Treat Post-traumatic Stress Disorder-like Memory in Mice: Optogenetics and Behavioral Approaches

    One of the cardinal features of post-traumatic stress disorder (PTSD) is a paradoxical memory alteration including both emotional hypermnesia for salient trauma-related cues and amnesia for the surrounding traumatic context. Interestingly, some

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    A Simple Spatial-independent Associative and Reversal Learning Task in Mice
    Authors:  Fulvio Magara, Benjamin Boury-Jamot and Hanna Hörnberg, date: 08/05/2021, view: 1726, Q&A: 0

    The ability to adapt one's behavior in response to changing circumstances, or cognitive flexibility, is often altered in neuropsychiatric and neurodevelopmental conditions. In rodents, cognitive flexibility is frequently assessed using associative

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