Education
MD in School of Medicine, National Yang-Ming University, Taipei, Taiwan, 1984
D.Phil. in the Department of Biochemistry, University of Oxford, 1992
Current position
Director, Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
Publications (Since 2005)
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Chen, S. T., Liu, R. S., Wu, M. F., Lin, Y. L., Chen, S. Y., Tan, D. T., Chou, T. Y., Tsai, I. S., Li, L. and Hsieh, S. L.* (2012). CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality. PLoS Pathog 8(4): e1002655.
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Tai, S. K., Chang, H. C., Lan, K. L., Lee, C. T., Yang, C. Y., Chen, N. J., Chou, T. Y., Tarng, D. C. and Hsieh, S. L.* (2012). Decoy receptor 3 enhances tumor progression via induction of tumor-associated macrophages. J Immunol 188(5): 2464-2471.
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Kuo, S. C., Lee, Y. T., Yang, S. P., Chen, C. P., Chen, T. L., Hsieh, S. L., Siu, L. K. and Fung, C. P. (2012). Eradication of multidrug-resistant Acinetobacter baumannii from the respiratory tract with inhaled colistin methanesulfonate: a matched case-control study. Clin Microbiol Infect 18(9): 870-876.
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Hwang, S. J., Chang, S. C., Yu, C. J., Chan, Y. J., Chen, T. J., Hsieh, S. L., Lai, H. Y., Lin, M. H., Liu, J. Y., Ong, G., Roman, F., Drame, M., Bock, H. L. and Yang, P. C. (2011). Immunogenicity and safety of an AS03(A)-adjuvanted H5N1 influenza vaccine in a Taiwanese population. J Formos Med Assoc 110(12): 780-786.
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Lin, W. W. and Hsieh, S. L.* (2011). Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer. Biochem Pharmacol 81(7): 838-847.
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Tai, S. K., Yang, M. H., Chang, S. Y., Chang, Y. C., Li, W. Y., Tsai, T. L., Wang, Y. F., Chu, P. Y. and Hsieh, S. L.* (2011). Persistent Kruppel-like factor 4 expression predicts progression and poor prognosis of head and neck squamous cell carcinoma. Cancer Sci 102(4): 895-902.
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Lee, R. T., Hsu, T. L., Huang, S. K., Hsieh, S. L., Wong, C. H. and Lee, Y. C. (2011). Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities. Glycobiology 21(4): 512-520.
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Kuo, W. C., Yang, K. T., Hsieh, S. L. and Lai, M. Z. (2010). Ezrin is a negative regulator of death receptor-induced apoptosis. Oncogene 29(9): 1374-1383.
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Liu, P. F., Shi, W., Zhu, W., Smith, J. W., Hsieh, S. L., Gallo, R. L. and Huang, C. M. (2010). Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: Implication for treatment of periodontal infection and halitosis. Vaccine 28(19): 3496-3505.
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Hsu, T. L., Cheng, S. C., Yang, W. B., Chin, S. W., Chen, B. H., Huang, M. T., Hsieh, S. L.** and Wong, C. H.** (2009). Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins. J Biol Chem 284(50): 34479-34489.
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Wu, M. F., Yang, C. Y., Lin, T. L., Wang, J. T., Yang, F. L., Wu, S. H., Hu, B. S., Chou, T. Y., Tsai, M. D., Lin, C. H. and Hsieh, S. L.* (2009). Humoral immunity against capsule polysaccharide protects the host from magA+ Klebsiella pneumoniae-induced lethal disease by evading Toll-like receptor 4 signaling. Infect Immun 77(2): 615-621.
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Chen, C. Y., Yang, K. Y., Chen, M. Y., Chen, H. Y., Lin, M. T., Lee, Y. C., Perng, R. P., Hsieh, S. L., Yang, P. C. and Chou, T. Y. (2009). Decoy receptor 3 levels in peripheral blood predict outcomes of acute respiratory distress syndrome. Am J Respir Crit Care Med 180(8): 751-760.
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Chao, W.-W., Kuo, Y.-H., Hsieh, S.-L. and Lin, B.-F. (2011). Inhibitory effects of ethyl acetate extract of Andrographis paniculata on NF-κB trans-activation activity and LPS-induced acute inflammation in mice. Evidence-Based Complementary and Alternative Medicine 2011.
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Hsieh, S.L.*, Decoy Receptor 3 (DcR3): A Pleiotropic Immunomodulator. Blood, 112, 916-917.
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Chen, S. T., Lin, Y. L., Huang, M. T., Wu, M. F., Cheng, S. C., Lei, H. Y., Lee, C. K., Chiou, T. W., Wong, C. H. and Hsieh, S. L.* (2008). CLEC5A is critical for dengue-virus-induced lethal disease. Nature 453(7195): 672-676.
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Chang, Y. C., Chen, T. C., Lee, C. T., Yang, C. Y., Wang, H. W., Wang, C. C. and Hsieh, S. L.* (2008). Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3. Blood 111(10): 5054-5063.
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You, R. I., Chang, Y. C., Chen, P. M., Wang, W. S., Hsu, T. L., Yang, C. Y., Lee, C. T. and Hsieh, S. L.* (2008). Apoptosis of dendritic cells induced by decoy receptor 3 (DcR3). Blood 111(3): 1480-1488.
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Lee, C. S., Hu, C. Y., Tsai, H. F., Wu, C. S., Hsieh, S. L., Liu, L. C. and Hsu, P. N. (2008). Elevated serum decoy receptor 3 with enhanced T cell activation in systemic lupus erythematosus. Clin Exp Immunol 151(3): 383-390.
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Wang, S. K., Liang, P. H., Astronomo, R. D., Hsu, T. L., Hsieh, S. L., Burton, D. R. and Wong, C. H. (2008). Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN. Proc Natl Acad Sci U S A 105(10): 3690-3695.
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Chen, M. L., Adak, A. K., Yeh, N. C., Yang, W. B., Chuang, Y. J., Wong, C. H., Hwang, K. C., Hwu, J. R., Hsieh, S. L. and Lin, C. C. (2008). Fabrication of an oriented Fc-fused lectin microarray through boronate formation. Angew Chem Int Ed Engl 47(45): 8627-8630.
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Tsai, C. M., Chiu, Y. K., Hsu, T. L., Lin, I. Y., Hsieh, S. L. and Lin, K. I. (2008). Galectin-1 promotes immunoglobulin production during plasma cell differentiation. J Immunol 181(7): 4570-4579.
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Chang, P. M., Chen, P. M., Hsieh, S. L., Tzeng, C. H., Liu, J. H., Chiou, T. J., Wang, W. S., Yen, C. C., Gau, J. P. and Yang, M. H. (2008). Expression of a soluble decoy receptor 3 in patients with diffuse large B-cell lymphoma predicts clinical outcome. Int J Oncol 33(3): 549-554.
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How, C. K., Chern, C. H., Wu, M. F., Wang, L. M., Huang, C. I., Lee, C. H. and Hsieh, S. L.* (2009). Expression of the triggering receptor expressed on myeloid cells-1 mRNA in a heterogeneous infected population. Int J Clin Pract 63(1): 126-133.
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Lian, W. N., Chang, C. H., Chen, Y. J., Dao, R. L., Luo, Y. C., Chien, J. Y., Hsieh, S. L. and Lin, C. H. (2007). Intracellular delivery can be achieved by bombarding cells or tissues with accelerated molecules or bacteria without the need for carrier particles. Exp Cell Res 313(1): 53-64.
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Tang, C. H., Hsu, T. L., Lin, W. W., Lai, M. Z., Yang, R. S., Hsieh, S. L.** and Fu, W. M.** (2007). Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice. J Biol Chem 282(4): 2346-2354.
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Ho, C. H., Hsu, C. F., Fong, P. F., Tai, S. K., Hsieh, S. L. and Chen, C. J. (2007). Epstein-Barr virus transcription activator Rta upregulates decoy receptor 3 expression by binding to its promoter. J Virol 81(9): 4837-4847.
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Ka, S. M., Sytwu, H. K., Chang, D. M., Hsieh, S. L., Tsai, P. Y. and Chen, A. (2007). Decoy receptor 3 ameliorates an autoimmune crescentic glomerulonephritis model in mice. J Am Soc Nephrol 18(9): 2473-2485.
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Wei, C. Y., Chou, Y. H., Ho, F. M., Hsieh, S. L. and Lin, W. W. (2006). Signaling pathways of LIGHT induced macrophage migration and vascular smooth muscle cell proliferation. J Cell Physiol 209(3): 735-743.
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You, R. I., Chen, M. C., Wang, H. W., Chou, Y. C., Lin, C. H. and Hsieh, S. L.* (2006). Inhibition of lymphotoxin-beta receptor-mediated cell death by survivin-DeltaEx3. Cancer Res 66(6): 3051-3061.
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Chen, S. J., Chu, M. L., Wang, C. J., Liao, C. L., Hsieh, S. L., Sytwu, H. K. and Wang, C. C. (2006). Kinetic Th1/Th2 responses of transgenic mice with bacterial meningitis induced by Haemophilus influenzae. Clin Sci (Lond) 111(4): 253-263.
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Liu, S. J., Leng, C. H., Lien, S. P., Chi, H. Y., Huang, C. Y., Lin, C. L., Lian, W. C., Chen, C. J., Hsieh, S. L. and Chong, P. (2006). Immunological characterizations of the nucleocapsid protein based SARS vaccine candidates. Vaccine 24(16): 3100-3108.
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Su, W. B., Chang, Y. H., Lin, W. W. and Hsieh, S. L.* (2006). Differential regulation of interleukin-8 gene transcription by death receptor 3 (DR3) and type I TNF receptor (TNFRI). Exp Cell Res 312(3): 266-277.
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Chang, Y. C., Chan, Y. H., Jackson, D. G. and Hsieh, S. L.* (2006). The glycosaminoglycan-binding domain of decoy receptor 3 is essential for induction of monocyte adhesion. J Immunol 176(1): 173-180.
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Lu, Y. T., Yen, C. Y., Ho, H. C., Chen, C. J., Wu, M. F. and Hsieh, S. L. (2006). Preparation and characterization of monoclonal antibody against protein TREM-like transcript-1 (TLT-1). Hybridoma (Larchmt) 25(1): 20-26.
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Chen, S. J., Chu, M. L., Wang, C. J., Liao, C. L., Hsieh, S. L., Sytwu, H. K. and Wang, C. C. (2006). Kinetic Th1/Th2 responses of transgenic mice with bacterial meningitis induced by Haemophilus influenzae. Clin Sci (Lond) 111(4): 253-263.
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Chen, S. J., Liao, C. L., Hsieh, S. L., Chu, M. L., Fang, M. C., Sytwu, H. K. and Wang, C. C. (2006). Kinetics of adaptive immunity to Haemophilus influenzae type b meningitis in transgenic mice: evidence from diverse expression of double T1/T2 transgenes and Th1/Th2-related cytokines. Immunol Lett 105(1): 6-15.
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Chi, K. H., Liu, S. J., Li, C. P., Kuo, H. P., Wang, Y. S., Chao, Y. and Hsieh, S. L. (2005). Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma. J Immunother 28(2): 129-135.
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Huang, L. F., Liu, Y. K., Lu, C. A., Hsieh, S. L. and Yu, S. M. (2005). Production of human serum albumin by sugar starvation induced promoter and rice cell culture. Transgenic Res 14(5): 569-581.
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Wang, P. H., Lee, W. L., Juang, C. M., Yang, Y. H., Lo, W. H., Lai, C. R., Hsieh, S. L. and Yuan, C. C. (2005). Altered mRNA expressions of sialyltransferases in ovarian cancers. Gynecol Oncol 99(3): 631-639.
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Yang, C. R., Hsieh, S. L., Ho, F. M. and Lin, W. W. (2005). Decoy receptor 3 increases monocyte adhesion to endothelial cells via NF-kappa B-dependent up-regulation of intercellular adhesion molecule-1, VCAM-1, and IL-8 expression. J Immunol 174(3): 1647-1656.
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Chang, Y. H., Hsieh, S. L., Chao, Y., Chou, Y. C. and Lin, W. W. (2005). Proinflammatory effects of LIGHT through HVEM and LTbetaR interactions in cultured human umbilical vein endothelial cells. J Biomed Sci 12(2): 363-375.
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Hsu, T. L., Wu, Y. Y., Chang, Y. C., Yang, C. Y., Lai, M. Z., Su, W. B. and Hsieh, S. L.* (2005). Attenuation of Th1 response in decoy receptor 3 transgenic mice. J Immunol 175(8): 5135-5145.
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Hung, J. T., Liao, J. H., Lin, Y. C., Chang, H. Y., Wu, S. F., Chang, T. H., Kung, J. T., Hsieh, S. L., McDevitt, H. and Sytwu, H. K. (2005). Immunopathogenic role of TH1 cells in autoimmune diabetes: evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model. J Autoimmun 25(3): 181-192.