Education
Ph.D., The Ohio State University, U.S.A
Current position
Assistant Professor of Pediatric Surgery, Pediatric Surgery, The University of Texas Health Science Center at Houston, U.S.A
Publications (since 2003)
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Lee, H. J., Diaz, M. F., Ewere, A., Olson, S. D., Cox, C. S., Jr. and Wenzel, P. L. (2017). Focal adhesion kinase signaling regulates anti-inflammatory function of bone marrow mesenchymal stromal cells induced by biomechanical force. Cell Signal 38: 1-9.
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Lee, H. J., Diaz, M. F., Price, K. M., Ozuna, J. A., Zhang, S., Sevick-Muraca, E. M., Hagan, J. P. and Wenzel, P. L. (2017). Fluid shear stress activates YAP1 to promote cancer cell motility. Nat Commun 8: 14122.
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Diaz, M. F., Vaidya, A. B., Evans, S. M., Lee, H. J., Aertker, B. M., Alexander, A. J., Price, K. M., Ozuna, J. A., Liao, G. P., Aroom, K. R., Xue, H., Gu, L., Omichi, R., Bedi, S., Olson, S. D., Cox, C. S., Jr. and Wenzel, P. L. (2017). Biomechanical Forces Promote Immune Regulatory Function of Bone Marrow Mesenchymal Stromal Cells. Stem Cells 35(5): 1259-1272.
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Kota, D. J., Prabhakara, K. S., Toledano-Furman, N., Bhattarai, D., Chen, Q., DiCarlo, B., Smith, P., Triolo, F., Wenzel, P. L., Cox, C. S., Jr. and Olson, S. D. (2017). Prostaglandin E2 Indicates Therapeutic Efficacy of Mesenchymal Stem Cells in Experimental Traumatic Brain Injury. Stem Cells 35(5): 1416-1430.
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Diaz, M. F., Li, N., Lee, H. J., Adamo, L., Evans, S. M., Willey, H. E., Arora, N., Torisawa, Y. S., Vickers, D. A., Morris, S. A., Naveiras, O., Murthy, S. K., Ingber, D. E., Daley, G. Q., Garcia-Cardena, G. and Wenzel, P. L. (2015). Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis. J Exp Med 212(5): 665-680.
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Jang, I. H., Lu, Y. F., Zhao, L., Wenzel, P. L., Kume, T., Datta, S. M., Arora, N., Guiu, J., Lagha, M., Kim, P. G., Do, E. K., Kim, J. H., Schlaeger, T. M., Zon, L. I., Bigas, A., Burns, C. E. and Daley, G. Q. (2015). Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood 125(9): 1418-1426.
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Li, N., Diaz, M. F. and Wenzel, P. L. (2015). Application of fluid mechanical force to embryonic sources of hemogenic endothelium and hematopoietic stem cells. Methods Mol Biol 1212: 183-193.
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Arora, N., Wenzel, P. L., McKinney-Freeman, S. L., Ross, S. J., Kim, P. G., Chou, S. S., Yoshimoto, M., Yoder, M. C. and Daley, G. Q. (2014). Effect of developmental stage of HSC and recipient on transplant outcomes. Dev Cell 29(5): 621-628.
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Lee, H. J., Li, N., Evans, S. M., Diaz, M. F. and Wenzel, P. L. (2013). Biomechanical force in blood development: extrinsic physical cues drive pro-hematopoietic signaling. Differentiation 86(3): 92-103.
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Gustafsson, K., Heffner, G., Wenzel, P. L., Curran, M., Grawe, J., McKinney-Freeman, S. L., Daley, G. Q. and Welsh, M. (2013). The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity. Exp Cell Res 319(12): 1852-1864.
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Ouseph, M. M., Li, J., Chen, H. Z., Pecot, T., Wenzel, P., Thompson, J. C., Comstock, G., Chokshi, V., Byrne, M., Forde, B., Chong, J. L., Huang, K., Machiraju, R., de Bruin, A. and Leone, G. (2012). Atypical E2F repressors and activators coordinate placental development. Dev Cell 22(4): 849-862.
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Wenzel, P. L., Chong, J. L., Saenz-Robles, M. T., Ferrey, A., Hagan, J. P., Gomez, Y. M., Rajmohan, R., Sharma, N., Chen, H. Z., Pipas, J. M., Robinson, M. L. and Leone, G. (2011). Cell proliferation in the absence of E2F1-3. Dev Biol 351(1): 35-45.
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Chen, D., Pacal, M., Wenzel, P., Knoepfler, P. S., Leone, G. and Bremner, R. (2009). Division and apoptosis of E2f-deficient retinal progenitors. Nature 462(7275): 925-929.
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Chong, J. L., Wenzel, P. L., Saenz-Robles, M. T., Nair, V., Ferrey, A., Hagan, J. P., Gomez, Y. M., Sharma, N., Chen, H. Z., Ouseph, M., Wang, S. H., Trikha, P., Culp, B., Mezache, L., Winton, D. J., Sansom, O. J., Chen, D., Bremner, R., Cantalupo, P. G., Robinson, M. L., Pipas, J. M. and Leone, G. (2009). E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature 462(7275): 930-934.
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Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F. and Daley, G. Q. (2009). Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature 460(7252): 259-263.
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Adamo, L., Naveiras, O., Wenzel, P. L., McKinney-Freeman, S., Mack, P. J., Gracia-Sancho, J., Suchy-Dicey, A., Yoshimoto, M., Lensch, M. W., Yoder, M. C., Garcia-Cardena, G. and Daley, G. Q. (2009). Biomechanical forces promote embryonic haematopoiesis. Nature 459(7250): 1131-1135.
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Mosaliganti, K., Pan, T., Ridgway, R., Sharp, R., Cooper, L., Gulacy, A., Sharma, A., Irfanoglu, O., Machiraju, R., Kurc, T., de Bruin, A., Wenzel, P., Leone, G., Saltz, J. and Huang, K. (2008). An imaging workflow for characterizing phenotypical change in large histological mouse model datasets. J Biomed Inform 41(6): 863-873.
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Mosaliganti, K., Janoos, F., Sharp, R., Ridgway, R., Machiraju, R., Huang, K., Wenzel, P., deBruin, A., Leone, G. and Saltz, J. (2007). Detection and visualization of surface-pockets to enable phenotyping studies. IEEE Trans Med Imaging 26(9): 1283-1290.
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Chen, D., Opavsky, R., Pacal, M., Tanimoto, N., Wenzel, P., Seeliger, M. W., Leone, G. and Bremner, R. (2007). Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol 5(7): e179.
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Wenzel, P. L. and Leone, G. (2007). Expression of Cre recombinase in early diploid trophoblast cells of the mouse placenta. Genesis 45(3): 129-134.
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Wenzel, P. L. (2007). Role of the Rb tumor suppressor in regulation of stem cell proliferation. Scitizen.
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Sharp, R., Ridgway, R., Mosaliganti, K., Wenzel, P., Pan, T., de Bruin, A., Machiraju, R., Huang, K., Leone, G. and Saltz, J. (2007). Volume Rendering Phenotype Differences in Mouse Placenta Microscopy Data. Computing in Science & Engineering 9: 38-47.
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Wenzel, P. L., Wu, L., de Bruin, A., Chong, J. L., Chen, W. Y., Dureska, G., Sites, E., Pan, T., Sharma, A., Huang, K., Ridgway, R., Mosaliganti, K., Sharp, R., Machiraju, R., Saltz, J., Yamamoto, H., Cross, J. C., Robinson, M. L. and Leone, G. (2007). Rb is critical in a mammalian tissue stem cell population. Genes Dev 21(1): 85-97.
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Mosaliganti, K., Pan, T., Sharp, R., Ridgway, R., Iyengar, S., Gulacy, A., Wenzel, P., de Bruin, A., Machiraju, R., Huang, K., Leone, G. and Saltz, J. (2006). Registration and 3D visualization of large microscopy images. Proceedings of SPIE International Society of Optical Engineering 6144:61442V.
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Pan, T., Jewel, S., Catalyurek, U., Wenzel, P., Leone, G., Hastings, S., Oster, S., Langella, S., Kurc, T., Saltz, J. and Cowden, D. (2006). Virtual Microscopy: Distributed Image Storage, Retrieval, Analysis, and Visualization. In: Zomaya, A. Y. (ed). Parallel Computing for Bioinformatics and Computational Biology: Models, Enabling Technologies, and Case Studies: 737-763, Wiley.
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de Bruin, A., Wu, L., Saavedra, H. I., Wilson, P., Yang, Y., Rosol, T. J., Weinstein, M., Robinson, M. L. and Leone, G. (2003). Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proceedings of the National Academy of Sciences USA 100(11): 6546-6551.
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Wu, L., de Bruin, A., Saavedra, H. I., Starovic, M., Trimboli, A., Yang, Y., Opavska, J., Wilson, P., Thompson, J. C., Ostrowski, M. C., Rosol, T. J., Woollett, L. A., Weinstein, M., Cross, J. C., Robinson, M. L. and Leone, G. (2003). Extra-embryonic function of Rb is essential for embryonic development and viability. Nature 421(6926): 942-947.
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Google Scholar Profile: https://scholar.google.com/citations?user=xS07KV0AAAAJ&hl=en
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MyNCBI Profile: http://www.ncbi.nlm.nih.gov/sites/myncbi/pamela.wenzel.1/bibliograpahy/41597399/public/?sort=date&direction=ascending