Education
Ph.D. (Dr, phil. II) in Developmental Biology and Genetics, Faculty of Science, Biozentrum, University of Basel, 1993
M.Sc. (Diplom) in Biology II (major: Cell Biology), Faculty of Science, Biozentrum, University of Basel, 1989
Current position
Professor of Plant Developmental Genetics, Institute of Plant Biology, University of Zürich, Switzerland
Publications (since 2010)
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Kessler, S. A., Lindner, H., Jones, D. S. and Grossniklaus, U. (2015). Functional analysis of related CrRLK1L receptor-like kinases in pollen tube reception. EMBO Rep 16(1): 107-115.
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Schmid, M. W. and Grossniklaus, U. (2015). Rcount: simple and flexible RNA-Seq read counting. Bioinformatics 31(3): 436-437.
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Schmidt, A., Schmid, M. W. and Grossniklaus, U. (2015). Plant germline formation: common concepts and developmental flexibility in sexual and asexual reproduction. Development 142(2): 229-241.
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Vogler, H., Felekis, D., Nelson, B. J. and Grossniklaus, U. (2015). Measuring the Mechanical Properties of Plant Cell Walls. Plants 4(2): 167-182.
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Singh, A. K., Bashir, T., Sailer, C., Gurumoorthy, V., Ramakrishnan, A. M., Dhanapal, S., Grossniklaus, U. and Baskar, R. (2015). Parental age affects somatic mutation rates in the progeny of flowering plants. Plant Physiol 168(1): 247-257.
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Felekis, D., Vogler, H., Mecja, G., Muntwyler, S., Nestorova, A., Huang, T., Sakar, M. S., Grossniklaus, U. and Nelson, B. J. (2015). Real-time automated characterization of 3D morphology and mechanics of developing plant cells. The International Journal of Robotics Research: 0278364914564231.
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Felekis D, Vogler H, Grossniklaus U, Nelson BJ (2015). Microrobotic tools for plant biology. In Emerging Tools for Micro and Nano Manipulation, Wiley-VCH, in press.
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Lindner, H., Kessler, S. A., Muller, L. M., Shimosato-Asano, H., Boisson-Dernier, A. and Grossniklaus, U. (2015). TURAN and EVAN mediate pollen tube reception in Arabidopsis Synergids through protein glycosylation. PLoS Biol 13(4): e1002139.
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Gossmann, T. I., Schmid, M. W., Grossniklaus, U. and Schmid, K. J. (2014). Selection-driven evolution of sex-biased genes is consistent with sexual selection in Arabidopsis thaliana. Mol Biol Evol 31(3): 574-583.
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Sailer, C., Schmid, B., Stöcklin, J. and Grossniklaus, U. (2014). Sexual Hieracium pilosella plants are better inter-specific, while apomictic plants are better intra-specific competitors. Perspectives in Plant Ecology, Evolution and Systematics 16(2): 43-51.
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Bashir, T., Sailer, C., Gerber, F., Loganathan, N., Bhoopalan, H., Eichenberger, C., Grossniklaus, U. and Baskar, R. (2014). Hybridization alters spontaneous mutation rates in a parent-of-origin-dependent fashion in Arabidopsis. Plant Physiol 165(1): 424-437.
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Ngo, Q. A., Vogler, H., Lituiev, D. S., Nestorova, A. and Grossniklaus, U. (2014). A calcium dialog mediated by the FERONIA signal transduction pathway controls plant sperm delivery. Dev Cell 29(4): 491-500.
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Schmidt, A., Schmid, M. W., Klostermeier, U. C., Qi, W., Guthorl, D., Sailer, C., Waller, M., Rosenstiel, P. and Grossniklaus, U. (2014). Apomictic and sexual germline development differ with respect to cell cycle, transcriptional, hormonal and epigenetic regulation. PLoS Genet 10(7): e1004476.
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Grob, S., Schmid, M. W. and Grossniklaus, U. (2014). Hi-C analysis in Arabidopsis identifies the KNOT, a structure with similarities to the flamenco locus of Drosophila. Mol Cell 55(5): 678-693.
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Felekis, D., Vogler, H., Mecja, G., Muntwyler, S., Sakar, M. S., Grossniklaus, U. and Nelson, B. J. (2014). High-throughput analysis of the morphology and mechanics of tip growing cells using a microrobotic platform. Intelligent Robots and Systems (IROS 2014), 2014 IEEE/RSJ International Conference on, IEEE.
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Lituiev, D. S. and Grossniklaus, U. (2014). Patterning of the angiosperm female gametophyte through the prism of theoretical paradigms. Biochem Soc Trans 42(2): 332-339.
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Pires, N. D. and Grossniklaus, U. (2014). Different yet similar: evolution of imprinting in flowering plants and mammals. F1000Prime Rep 6: 63.
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Grossniklaus, U. and Paro, R. (2014). Transcriptional silencing by polycomb-group proteins. Cold Spring Harb Perspect Biol 6(11): a019331.
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Wuest, S. E. and Grossniklaus, U. (2014). Laser-assisted microdissection applied to floral tissues. Methods Mol Biol 1110: 329-344.
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Ngo, Q. A., Albrecht, H., Tsuchimatsu, T. and Grossniklaus, U. (2013). The differentially regulated genes TvQR1 and TvPirin of the parasitic plant Triphysaria exhibit distinctive natural allelic diversity. BMC Plant Biol 13: 28.
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Vogler, H., Draeger, C., Weber, A., Felekis, D., Eichenberger, C., Routier-Kierzkowska, A. L., Boisson-Dernier, A., Ringli, C., Nelson, B. J., Smith, R. S. and Grossniklaus, U. (2013). The pollen tube: a soft shell with a hard core. Plant J 73(4): 617-627.
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Schmidt, A., Wohrmann, H. J., Raissig, M. T., Arand, J., Gheyselinck, J., Gagliardini, V., Heichinger, C., Walter, J. and Grossniklaus, U. (2013). The Polycomb group protein MEDEA and the DNA methyltransferase MET1 interact to repress autonomous endosperm development in Arabidopsis. Plant J 73(5): 776-787.
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Lindner, M., Simonini, S., Kooiker, M., Gagliardini, V., Somssich, M., Hohenstatt, M., Simon, R., Grossniklaus, U. and Kater, M. M. (2013). TAF13 interacts with PRC2 members and is essential for Arabidopsis seed development. Dev Biol 379(1): 28-37.
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Sedeek, K. E., Qi, W., Schauer, M. A., Gupta, A. K., Poveda, L., Xu, S., Liu, Z. J., Grossniklaus, U., Schiestl, F. P. and Schluter, P. M. (2013). Transcriptome and proteome data reveal candidate genes for pollinator attraction in sexually deceptive orchids. PLoS One 8(5): e64621.
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Raissig, M. T., Gagliardini, V., Jaenisch, J., Grossniklaus, U. and Baroux, C. (2013). Efficient and rapid isolation of early-stage embryos from Arabidopsis thaliana seeds. J Vis Exp(76).
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Lituiev, D. S., Krohn, N. G., Muller, B., Jackson, D., Hellriegel, B., Dresselhaus, T. and Grossniklaus, U. (2013). Theoretical and experimental evidence indicates that there is no detectable auxin gradient in the angiosperm female gametophyte. Development 140(22): 4544-4553.
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Grob, S., Schmid, M. W., Luedtke, N. W., Wicker, T. and Grossniklaus, U. (2013). Characterization of chromosomal architecture in Arabidopsis by chromosome conformation capture. Genome Biol 14(11): R129.
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Boisson-Dernier, A., Lituiev, D. S., Nestorova, A., Franck, C. M., Thirugnanarajah, S. and Grossniklaus, U. (2013). ANXUR receptor-like kinases coordinate cell wall integrity with growth at the pollen tube tip via NADPH oxidases. PLoS Biol 11(11): e1001719.
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Raissig, M. T., Bemer, M., Baroux, C. and Grossniklaus, U. (2013). Genomic imprinting in the Arabidopsis embryo is partly regulated by PRC2. PLoS Genet 9(12): e1003862.
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Wuest, S. E., Schmid, M. W. and Grossniklaus, U. (2013). Cell-specific expression profiling of rare cell types as exemplified by its impact on our understanding of female gametophyte development. Curr Opin Plant Biol 16(1): 41-49.
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Baroux, C., Autran, D., Raissig, M. T., Grimanelli, D. and Grossniklaus, U. (2013). Parental contributions to the transcriptome of early plant embryos. Curr Opin Genet Dev 23(1): 72-74.
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Grossniklaus, U., Kelly, W. G., Ferguson-Smith, A. C., Pembrey, M. and Lindquist, S. (2013). Transgenerational epigenetic inheritance: how important is it? Nat Rev Genet 14(3): 228-235.
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Barrell, P. and Grossniklaus, U. (2013). Examining female meiocytes of maize by confocal microscopy. Methods Mol Biol 990: 45-52.
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Hirsch S, Baumberger R, Grossniklaus U (2013). Epigenetic variation, inheritance, and selection in plant populations. Cold Spring Harb Symp Quant Biol 77, 97-104.
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Schmid, M. W., Schmidt, A., Klostermeier, U. C., Barann, M., Rosenstiel, P. and Grossniklaus, U. (2012). A powerful method for transcriptional profiling of specific cell types in eukaryotes: laser-assisted microdissection and RNA sequencing. PLoS One 7(1): e29685.
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Petricka, J. J., Schauer, M. A., Megraw, M., Breakfield, N. W., Thompson, J. W., Georgiev, S., Soderblom, E. J., Ohler, U., Moseley, M. A., Grossniklaus, U. and Benfey, P. N. (2012). The protein expression landscape of the Arabidopsis root. Proc Natl Acad Sci U S A 109(18): 6811-6818.
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You, W., Tyczewska, A., Spencer, M., Daxinger, L., Schmid, M. W., Grossniklaus, U., Simon, S. A., Meyers, B. C., Matzke, A. J. and Matzke, M. (2012). Atypical DNA methylation of genes encoding cysteine-rich peptides in Arabidopsis thaliana. BMC Plant Biol 12: 51.
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Mayank, P., Grossman, J., Wuest, S., Boisson-Dernier, A., Roschitzki, B., Nanni, P., Nuhse, T. and Grossniklaus, U. (2012). Characterization of the phosphoproteome of mature Arabidopsis pollen. Plant J 72(1): 89-101.
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Lindner, H., Raissig, M. T., Sailer, C., Shimosato-Asano, H., Bruggmann, R. and Grossniklaus, U. (2012). SNP-Ratio Mapping (SRM): identifying lethal alleles and mutations in complex genetic backgrounds by next-generation sequencing. Genetics 191(4): 1381-1386.
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Marshall, A., Aalen, R. B., Audenaert, D., Beeckman, T., Broadley, M. R., Butenko, M. A., Cano-Delgado, A. I., de Vries, S., Dresselhaus, T., Felix, G., Graham, N. S., Foulkes, J., Granier, C., Greb, T., Grossniklaus, U., Hammond, J. P., Heidstra, R., Hodgman, C., Hothorn, M., Inze, D., Ostergaard, L., Russinova, E., Simon, R., Skirycz, A., Stahl, Y., Zipfel, C. and De Smet, I. (2012). Tackling drought stress: receptor-like kinases present new approaches. Plant Cell 24(6): 2262-2278.
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Wohrmann, H. J., Gagliardini, V., Raissig, M. T., Wehrle, W., Arand, J., Schmidt, A., Tierling, S., Page, D. R., Schob, H., Walter, J. and Grossniklaus, U. (2012). Identification of a DNA methylation-independent imprinting control region at the Arabidopsis MEDEA locus. Genes Dev 26(16): 1837-1850.
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Leshem, Y., Johnson, C., Wuest, S. E., Song, X., Ngo, Q. A., Grossniklaus, U. and Sundaresan, V. (2012). Molecular characterization of the glauce mutant: a central cell-specific function is required for double fertilization in Arabidopsis. Plant Cell 24(8): 3264-3277.
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Xu, S., Schluter, P. M., Grossniklaus, U. and Schiestl, F. P. (2012). The genetic basis of pollinator adaptation in a sexually deceptive orchid. PLoS Genet 8(8): e1002889.
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Kritsas, K., Wuest, S. E., Hupalo, D., Kern, A. D., Wicker, T. and Grossniklaus, U. (2012). Computational analysis and characterization of UCE-like elements (ULEs) in plant genomes. Genome Res 22(12): 2455-2466.
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Zust, T., Heichinger, C., Grossniklaus, U., Harrington, R., Kliebenstein, D. J. and Turnbull, L. A. (2012). Natural enemies drive geographic variation in plant defenses. Science 338(6103): 116-119.
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Ngo, Q. A., Baroux, C., Guthorl, D., Mozerov, P., Collinge, M. A., Sundaresan, V. and Grossniklaus, U. (2012). The Armadillo repeat gene ZAK IXIK promotes Arabidopsis early embryo and endosperm development through a distinctive gametophytic maternal effect. Plant Cell 24(10): 4026-4043.
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Iwano, M., Ngo, Q. A., Entani, T., Shiba, H., Nagai, T., Miyawaki, A., Isogai, A., Grossniklaus, U. and Takayama, S. (2012). Cytoplasmic Ca2+ changes dynamically during the interaction of the pollen tube with synergid cells. Development 139(22): 4202-4209.
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Sprunck, S., Rademacher, S., Vogler, F., Gheyselinck, J., Grossniklaus, U. and Dresselhaus, T. (2012). Egg cell-secreted EC1 triggers sperm cell activation during double fertilization. Science 338(6110): 1093-1097.
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Jones, A. M., Aebersold, R., Ahrens, C. H., Apweiler, R., Baerenfaller, K., Baker, M., Bendixen, E., Briggs, S., Brownridge, P., Brunner, E., Daube, M., Deutsch, E. W., Grossniklaus, U., Heazlewood, J., Hengartner, M. O., Hermjakob, H., Jovanovic, M., Lawless, C., Lochnit, G., Martens, L., Ravnsborg, C., Schrimpf, S. P., Shim, Y. H., Subasic, D., Tholey, A., Wijk, K., Mering, C., Weiss, M. and Zheng, X. (2012). The HUPO initiative on Model Organism Proteomes, iMOP. Proteomics 12(3): 340-345.
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Schmidt, A., Schmid, M. W. and Grossniklaus, U. (2012). Analysis of plant germline development by high-throughput RNA profiling: technical advances and new insights. Plant J 70(1): 18-29.
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Lindner, H., Muller, L. M., Boisson-Dernier, A. and Grossniklaus, U. (2012). CrRLK1L receptor-like kinases: not just another brick in the wall. Curr Opin Plant Biol 15(6): 659-669.
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Pires, N. D. and Grossniklaus, U. (2012). How to fine-tune an epigenetic switch. Dev Cell 23(3): 453-454.
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Bemer, M. and Grossniklaus, U. (2012). Dynamic regulation of Polycomb group activity during plant development. Curr Opin Plant Biol 15(5): 523-529.
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Hirsch, S., Baumberger, R. and Grossniklaus, U. (2012). Epigenetic variation, inheritance, and selection in plant populations. Cold Spring Harb Symp Quant Biol 77: 97-104.
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Dumbliauskas, E., Lechner, E., Jaciubek, M., Berr, A., Pazhouhandeh, M., Alioua, M., Cognat, V., Brukhin, V., Koncz, C., Grossniklaus, U., Molinier, J. and Genschik, P. (2011). The Arabidopsis CUL4-DDB1 complex interacts with MSI1 and is required to maintain MEDEA parental imprinting. EMBO J 30(4): 731-743.
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Brukhin, V. B., Jaciubek, M., Bolanos Carpio, A., Kuzmina, V. and Grossniklaus, U. (2011). Female gametophytic mutants of Arabidopsis thaliana identified in a gene trap insertional mutagenesis screen. Int J Dev Biol 55(1): 73-84.
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Felekis, D., Muntwyler, S., Vogler, H., Beyeler, F., Grossniklaus, U. and Nelson, B. (2011). Quantifying growth mechanics of living, growing plant cells in situ using microrobotics. Micro & Nano Letters 6(5): 311-316.
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Koszegi, D., Johnston, A. J., Rutten, T., Czihal, A., Altschmied, L., Kumlehn, J., Wust, S. E., Kirioukhova, O., Gheyselinck, J., Grossniklaus, U. and Baumlein, H. (2011). Members of the RKD transcription factor family induce an egg cell-like gene expression program. Plant J 67(2): 280-291.
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Schluter, P. M., Xu, S., Gagliardini, V., Whittle, E., Shanklin, J., Grossniklaus, U. and Schiestl, F. P. (2011). Stearoyl-acyl carrier protein desaturases are associated with floral isolation in sexually deceptive orchids. Proc Natl Acad Sci U S A 108(14): 5696-5701.
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Autran, D., Baroux, C., Raissig, M. T., Lenormand, T., Wittig, M., Grob, S., Steimer, A., Barann, M., Klostermeier, U. C., Leblanc, O., Vielle-Calzada, J. P., Rosenstiel, P., Grimanelli, D. and Grossniklaus, U. (2011). Maternal epigenetic pathways control parental contributions to Arabidopsis early embryogenesis. Cell 145(5): 707-719.
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Kirioukhova, O., Johnston, A. J., Kleen, D., Kagi, C., Baskar, R., Moore, J. M., Baumlein, H., Gross-Hardt, R. and Grossniklaus, U. (2011). Female gametophytic cell specification and seed development require the function of the putative Arabidopsis INCENP ortholog WYRD. Development 138(16): 3409-3420.
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McKeown, P. C., Laouielle-Duprat, S., Prins, P., Wolff, P., Schmid, M. W., Donoghue, M. T., Fort, A., Duszynska, D., Comte, A., Lao, N. T., Wennblom, T. J., Smant, G., Kohler, C., Grossniklaus, U. and Spillane, C. (2011). Identification of imprinted genes subject to parent-of-origin specific expression in Arabidopsis thaliana seeds. BMC Plant Biol 11: 113.
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Schmidt, A., Wuest, S. E., Vijverberg, K., Baroux, C., Kleen, D. and Grossniklaus, U. (2011). Transcriptome analysis of the Arabidopsis megaspore mother cell uncovers the importance of RNA helicases for plant germline development. PLoS Biol 9(9): e1001155.
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Boisson-Dernier, A., Kessler, S. A. and Grossniklaus, U. (2011). The walls have ears: the role of plant CrRLK1Ls in sensing and transducing extracellular signals. J Exp Bot 62(5): 1581-1591.
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Raissig, M. T., Baroux, C. and Grossniklaus, U. (2011). Regulation and flexibility of genomic imprinting during seed development. Plant Cell 23(1): 16-26.
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Baroux, C., Raissig, M. T. and Grossniklaus, U. (2011). Epigenetic regulation and reprogramming during gamete formation in plants. Curr Opin Genet Dev 21(2): 124-133.
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Paszkowski, J. and Grossniklaus, U. (2011). Selected aspects of transgenerational epigenetic inheritance and resetting in plants. Curr Opin Plant Biol 14(2): 195-203.
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Grossniklaus, U. (2011). Plant germline development: a tale of cross-talk, signaling, and cellular interactions. Sex Plant Reprod 24(2): 91-95.
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Kessler, S. A. and Grossniklaus, U. (2011). She's the boss: signaling in pollen tube reception. Curr Opin Plant Biol 14(5): 622-627.
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Aquea, F., Johnston, A. J., Canon, P., Grossniklaus, U. and Arce-Johnson, P. (2010). TRAUCO, a Trithorax-group gene homologue, is required for early embryogenesis in Arabidopsis thaliana. J Exp Bot 61(4): 1215-1224.
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Pillot, M., Baroux, C., Vazquez, M. A., Autran, D., Leblanc, O., Vielle-Calzada, J. P., Grossniklaus, U. and Grimanelli, D. (2010). Embryo and endosperm inherit distinct chromatin and transcriptional states from the female gametes in Arabidopsis. Plant Cell 22(2): 307-320.
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Wuest, S. E., Vijverberg, K., Schmidt, A., Weiss, M., Gheyselinck, J., Lohr, M., Wellmer, F., Rahnenfuhrer, J., von Mering, C. and Grossniklaus, U. (2010). Arabidopsis female gametophyte gene expression map reveals similarities between plant and animal gametes. Curr Biol 20(6): 506-512.
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Matias-Hernandez, L., Battaglia, R., Galbiati, F., Rubes, M., Eichenberger, C., Grossniklaus, U., Kater, M. M. and Colombo, L. (2010). VERDANDI is a direct target of the MADS domain ovule identity complex and affects embryo sac differentiation in Arabidopsis. Plant Cell 22(6): 1702-1715.
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Johnston, A. J., Kirioukhova, O., Barrell, P. J., Rutten, T., Moore, J. M., Baskar, R., Grossniklaus, U. and Gruissem, W. (2010). Dosage-sensitive function of retinoblastoma related and convergent epigenetic control are required during the Arabidopsis life cycle. PLoS Genet 6(6): e1000988.
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Fakheran, S., Paul-Victor, C., Heichinger, C., Schmid, B., Grossniklaus, U. and Turnbull, L. A. (2010). Adaptation and extinction in experimentally fragmented landscapes. Proc Natl Acad Sci U S A 107(44): 19120-19125.
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Keinath, N. F., Kierszniowska, S., Lorek, J., Bourdais, G., Kessler, S. A., Shimosato-Asano, H., Grossniklaus, U., Schulze, W. X., Robatzek, S. and Panstruga, R. (2010). PAMP (pathogen-associated molecular pattern)-induced changes in plasma membrane compartmentalization reveal novel components of plant immunity. J Biol Chem 285(50): 39140-39149.
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Kessler, S. A., Shimosato-Asano, H., Keinath, N. F., Wuest, S. E., Ingram, G., Panstruga, R. and Grossniklaus, U. (2010). Conserved molecular components for pollen tube reception and fungal invasion. Science 330(6006): 968-971.
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Muller, B. and Grossniklaus, U. (2010). Model organisms--A historical perspective. J Proteomics 73(11): 2054-2063.
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Pien, S. and Grossniklaus, U. (2010). Chromatin immunoprecipitation protocol for histone modifications and protein-DNA binding analyses in Arabidopsis. Methods Mol Biol 631: 209-220.