Madhu Sudhana Saddala
  • Post-Doc, Johns Hopkins University School of Medicine
Research focus
  • Bioinformatics
  • Investigate endogenous small molecular changes in normal and diseased retina and retinal pigment epithelium (RPE) by genomics and proteomics level.

Lab information

Dr. Huang Lab


1. Madhu Sudhana Saddala and Mir Asif Iquebal (2017). De novo assembly, genome wide identification of differential gene expressions, SNPs and SSRs in wild and mutant of Kerria lacca. BMC Genomics. (IF: 3.8)
2. Madhu Sudhana Saddala, Naina Patyal and Pradeep Kiran Jangampalli Adi (2017). Genome wide identification of genes involved in Arabidopsis thaliana under high light conditions data analysis: Bioconductor. BMC Genomics. (IF: 3.8)
3. Madhu Sudhana Saddala and Pradeep Kiran Jangampalli Adi (2017). Functional analysis and biotechnological application of genes involved in drought and salt stress tolerance in Arabidopsis thaliana. Gene journal. (IF: 2.3)

1. Mundla Sri Latha, Madhu Sudhana Saddala (2017). Molecular docking based screening of a simulated HIF-1 protein model for potential inhibitors. Bioinformation. 13(11) 388-394 (IF: 0.80)
2. Janaki Ramudu D.B, Subba Rao Devineni, Srikanth Chilakuru, Madhu Sudhana Saddala, Sreenivasa Murthy P, Nagalakshmi Devamma M, Chalapathi P. V. and Naga Raju C. (2017). Sulfonamides and carbamates of 3-fluoro-4-morpholinoaniline (Linezolid intermediate): Synthesis, antimicrobial activity and molecular docking study. Research on Chemical Intermediates. 44(1) 469–489 (IF: 1.36)
3. Madhu Sudhana Saddala, Ramesh Kandimalla, Pradeep Kiran Jangampalli Adi, Sainath Sri Bhashyam and Usha Rani Asupatri (2017). Novel 1,4-dihydropyridines for L-type calcium channel as antagonists for cadmium toxicity. Scientific Reports. 7, 45211: 1-13. IF: 4.2 DOI: 10.1038/srep45211
4. Subba Rao Devineni, Madhava Golla, Thaslim Basha Shaik, Janardhan Avilala, Madhu Sudhana Saddala, Narasimha Golla, Chamarthi Naga Raju (2017). Ethyl phosphoramidates of acyclovir: Design, synthesis, molecular docking (HN Protein) and evaluation of antiviral and antioxidant activities. Medicinal Chemistry Research. 26, 999-1009 IF: 1.27 DOI: 10.1007/s00044-017-1819-8
5. Madhava Golla, Venkata Ramana Katla, Madhu Sudhana Saddala, Lokanatha Valluru, Hema Kumar Kuntrapakam, Usha Rani Asupatri and Raju chamarthi (2017). Synthesis, Anti-inflammatory evaluation and Molecular docking studies of N-substituted aryl/heteroaryl-pyrazol-1-yl benzenesulfonamide (Celecoxib) derivatives as COX-2 inhibitors. Medicinal Chemistry. 13 (1):1–14. (IF: 2.3). DOI: 10.2174/1573406413666170221093740
6. Madhu Sudhana Saddala and A. Usha Rani (2017). Homology modelling, structure based pharmacophore modelling, high throughput virtual screening and docking studies of L-type calcium channel for cadmium toxicity. Book: Translational Bioinformatics and Its Application, Editor-in-Chief: Dongqing Wei. ISBN: 978-94-024-1043-3. 153-176. DOI 10.1007/978-94-024-1045-7_7
7. H. Sudhamani, S. K. Thaslim Basha, S. Adam, S. Madhu Sudhana, A. Usha Rani and C. Naga Raju (2017). Synthesis and evaluation of urea and thiourea derivatives of lopinavir intermediate as potent antimicrobial, antioxidant agents and molecular docking studies against Staphopain. Research on Chemical Intermediates. 43 (1):1–18. (IF: 1.36) DOI 10.1007/s11164-016-2609-5
8. Madhu Sudhana Saddala, Pradeep Kiran Jangampalli Adi and Usha Rani A (2016). Molecular Docking and Active site Identification of Cathepsin-L (CAT-L) for SARS Disease. Journal of Research and Development. 4(2):1–4.
9. Madhu Sudhana Saddala, Pradeep Kiran Jangampalli Adi, Vengala Rao Patchava and Usha Rani A (2016). Selenoergothionein as a potential inhibitor against amyloid β-protein (aβ): Docking and molecular dynamics studies. International Journal of Biomedical Data Mining. 5(2):1–4. (IF: 0.20) DOI:10.4172/2090-4924.1000120
10. Subba Rao Devineni, Madhava Golla, Naga Raju Chamarthi, Balaji Meriga, Madhu Sudhana Saddala and Usha Rani Asupathri (2016). 2-Amino-2,3-dihydro-1H-2λ5-[1,3,2] diazaphospholo[4,5-b] pyridine-2-one based urea and thiourea derivatives: Synthesis, molecular docking study and evaluation of anti-inflammatory and antimicrobial activities. Medicinal Chemistry Research. 25(4):751–768 (IF: 1.27) DOI 10.1007/s00044-016-1518-x
11. M. Vijaya Bhaskara Reddy, D. Srinivasulu, S. Madhu Sudhana, B. Srikanth, A. Usha Rani and C. Naga Raju (2015). Inhibition of LPS-induced NO production in RAW264.7 cell lines: synthesis and molecular modeling of α-ketophosphonates of febuxostat. Phosphorus sulfur and silicon and the related elements. 191(1):144–149 (IF-0.80). DOI: 10.1080/10426507.2015.1050018
12. Sk Thaslim Basha, Devineni Subba Rao, Golla Madhava, Shaik Thahir Basha, Mundla Nagalakshmi Devamma, Saddala Madhu Sudhana, Asupatri Usha Rani and Chamarthi Naga Raju (2015). N-Phosphorylated Derivatives of 5-Nitroindazole as Antimicrobial and Antioxidant Agents and Docking Study against DNA GyraseA. Phosphorus sulfur and silicon and the related elements, 190:1064–1074. (IF: 0.80) DOI: 10.1080/10426507.2014.965818
13. Madhu Sudhana Saddala, J. Obaiah and A. Usha Rani (2015). Identification of potent VEGFR-2 Inhibitors of Angiogenesis through homology modeling, structure based virtual screening, docking and molecular dynamics simulations. International Journal of Scientific and Engineering Research, 6 (4): 1382-1390. (IF: 3.8)
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