Mammalia

Categories

    Protocols in Current Issue
    Displaced Object Recognition Memory in Rats
    Authors:  Ali N. Mclagan and Jena B. Hales, date: 04/20/2019, view: 423, Q&A: 0
    [Abstract] The Displaced Object Recognition (DOR) task, sometimes called the Novel Object Location task, assesses spatial recognition memory without navigational demands, explicit instruction, or the need for multiple days of training. This memory task has two phases. First, the subject is familiarized to an open arena with two objects and is allowed to ...
    Consummatory Successive Negative Contrast in Rats
    [Abstract] Using animal models in addiction and pain research is pivotal to unravel new pathways and mechanisms for the treatment of these disorders. Reward devaluation through a consummatory successive negative contrast (cSNC) task has shown the ability to reduce physical pain sensitivity (hypoalgesia) and increase oral ethanol consumption in rats. The ...
    Social Defeat Stress (SDS) in Mice: Using Swiss Mice as Resident
    Authors:  Marco Oreste F. Pagliusi Jr. and Cesar R. Sartori, date: 03/20/2019, view: 659, Q&A: 0
    [Abstract] Due to the high prevalence and great economic impact of depression, studies with animal models have been increasingly used to identify neurobiological mechanisms associated with this disorder. However, many animal models use stressful conditions that are not consistent with what we observe in the modern human world. Examples are the chronic ...
    Assessing Spatial Working Memory Using the Spontaneous Alternation Y-maze Test in Aged Male Mice
    Authors:  Emily A.K. Prieur and Nafisa M. Jadavji, date: 02/05/2019, view: 1295, Q&A: 0
    [Abstract] The global population is aging and the prevalence of age-related diseases, such as Alzheimer's disease and vascular dementia is increasing. Understanding functional impairments and disease processes is of vital importance in order to develop effective therapeutics. Using the natural exploratory behavior of mice, the spontaneous alternation y-maze ...
    Three-chamber Social Approach Task with Optogenetic Stimulation (Mice)
    Authors:  Celeste Leung, Jun Chul Kim and Zhengping Jia, date: 12/20/2018, view: 904, Q&A: 0
    [Abstract] The formation of social relationships via social interactions and memory are essential for one’s physical and mental health. To date, rodent studies have used the three-chamber social approach test to measure social approach, social novelty, and social memory. In recent years, techniques including optogenetics have been developed to acutely ...
    Behavioral Evaluation of Seeking and Preference of Alcohol in Mice Subjected to Stress
    Authors:  Ana Canseco-Alba, Norman Schanz, Hiroki Ishiguro, Qing-Rong Liu and Emmanuel S. Onaivi, date: 10/20/2018, view: 1071, Q&A: 0
    [Abstract] The alcohol preference model is one of the most widely used animal models relevant to alcoholism. Stressors increase alcohol consumption. Here we present a protocol for a rapid and useful tool to test alcohol preference and stress-induced alcohol consumption in mice. In this model, animals are given two bottles, one with a diluted solution of ...
    Behavioral Evaluation of Odor Memory in Mice
    Authors:  Afif J. Aqrabawi and Jun Chul Kim, date: 09/20/2018, view: 1056, Q&A: 0
    [Abstract] Behavioural tests based on the spontaneous recognition paradigm have been used extensively for examining the memory capacity of rodents. By exploiting their innate preference to investigate novel stimuli, inferences can be drawn about the perceived familiarity of encountered objects. Olfaction is the dominant sense used by mice to navigate their ...
    Shock-probe Defensive Burying Test to Measure Active versus Passive Coping Style in Response to an Aversive Stimulus in Rats
    Authors:  Elizabeth A. Fucich and David A. Morilak, date: 09/05/2018, view: 1167, Q&A: 0
    [Abstract] Maladaptive avoidance behaviors are seen in many stress-related psychiatric illnesses. Patients with these illnesses favor passive, avoidant coping strategies rather than adaptive, active coping strategies. Preclinically, coping strategy can be measured in rats using the shock-probe defensive burying test, wherein rats receive a shock from an ...
    Trace Fear Conditioning: Procedure for Assessing Complex Hippocampal Function in Mice
    [Abstract] The trace fear conditioning protocol is designed to measure hippocampal function in mice. The protocol includes a neutral conditioned stimulus (tone) and an aversive unconditioned stimulus (shock), separated in time by a trace interval. The trace interval between the tone and the shock critically involves the hippocampus and could be used to ...
    Sociability and Social Novelty Preference Tests Using a U-shaped Two-choice Field
    Authors:  Eun-Hwa Lee, Jin-Young Park, Yunjin Lee and Pyung-Lim  Han, date: 05/20/2018, view: 2361, Q&A: 0
    [Abstract] We developed sociability tests based on use of a U-shaped two-choice field to read out behavioral states of sociability in rodents. The U-shaped two-choice field is a modified open field that is partially partitioned with a wall projecting to the central point, resulting in two symmetrical rectangular fields, each containing closed and open square ...



    We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.