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    Protocols in Current Issue
    Fitness Determinations in Vesicular Stomatitis Virus
    Author:  Isabel S. Novella, date: 03/20/2014, view: 5302, Q&A: 0
    [Abstract] Fitness is defined as the overall replicative ability. Testing whether a mutation (or combination of mutations) has an effect on fitness often relays on determining virus production as a surrogate measurement. However, viruses do not usually replicate in a void, and evolutionary speaking, it is key to determine replicative ability compared to ...
    Measuring Genetic Robustness in Vesicular Stomatitis Virus
    Author:  Isabel S. Novella, date: 03/20/2014, view: 6164, Q&A: 0
    [Abstract] Genetic robustness is the ability of a genome to incorporate mutations with the result of no fitness changes. Thus, more robust viruses have an increased neutral mutation rate. This property is particularly important in RNA viruses due to their high mutation rates. The most direct way of measuring robustness in vesicular stomatitis virus (VSV) is ...



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