Cancer Biology


    Protocols in Current Issue
    ATAC-Seq-based Identification of Extrachromosomal Circular DNA in Mammalian Cells and Its Validation Using Inverse PCR and FISH
    Authors:  Zhangli Su, Shekhar Saha, Teressa Paulsen, Pankaj Kumar and Anindya Dutta, date: 05/05/2021, view: 3511, Q&A: 0

    Recent studies from multiple labs including ours have demonstrated the importance of extrachromosomal circular DNA (eccDNA) from yeast to humans (Shibata et al., 2012; Dillon et al., 2015; Møller et al., 2016; Kumar et al., 2017; Turner et al., 2017; Kim et al., 2020). More recently, it has been found that cancer cells obtain a selective

    Approaching RNA-seq for Cell Line Identification
    Authors:  Tabrez A. Mohammad and Yidong Chen, date: 02/05/2020, view: 2519, Q&A: 0
    [Abstract] Cancer cell lines serve as invaluable model systems for cancer biology research and help in evaluating the efficacy of new therapeutic agents. However, cell line contamination and misidentification have become one of the most pressing problems affecting biomedical research. Available methods of cell line authentication suffer from limited access, ...
    Genomic Signature of Homologous Recombination Deficiency in Breast and Ovarian Cancers
    Authors:  Tatiana Popova, Elodie Manié and Marc-Henri Stern , date: 07/05/2013, view: 13074, Q&A: 0
    [Abstract] Homologous recombination deficiency, mainly resulted from BRCA1 or BRCA2 inactivation (so called BRCAness), is found in breast and ovarian cancers. Detection of actual inactivation of BRCA1/2 in a tumor is important for patients’ treatment and follow-up as it may help predicting response to DNA damaging agents and give ...

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