Protocols in Current Issue
    Generation of IgG-Fc Glycovariants Using Recombinant Glycosidases and Glycosyltransferases
    Authors:  Isaak Quast, Michael A. Maurer and Jan D. Lünemann, date: 08/05/2016, view: 8647, Q&A: 0
    [Abstract] The immunoglobulin G (IgG) fragment crystallizable (Fc) domain contains a single, highly conserved asparagine 297 (N297) glycosylation site in the CH2 domain, which is buried within the hydrophobic core of each of the two heavy chains. The biantennary core glycan structure, composed of 2 N-acetylglucosamine (GlcNAc) and 3 mannose residues, can be ...

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