Cancer Biology

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    Protocols in Current Issue
    Evaluation of Mucosal and Systemic Vaccine Responses by Cyclic di-GMP (CDG)-adjuvanted Protein Subunit Vaccines
    Authors:  Samira Mansouri and Lei Jin, date: 04/20/2019, view: 2019, Q&A: 0
    [Abstract] Intranasal administration of vaccine adjuvants directly deliver therapeutic agents to the lungs to induce potent lung mucosal immune responses. Cyclic di-GMP (CDG) is a promising mucosal vaccine adjuvant candidate capable of inducing protective immunity. This protocol describes an in vivo approach to induce and detect mucosal (lung) and ...
    Human Blood Component Vaccinia Virus Neutralization Assay
    Authors:  Laura Evgin and John Bell, date: 12/05/2015, view: 6224, Q&A: 0
    [Abstract] Many therapeutic viruses, such as oncolytic viruses, vaccines, or gene therapy vectors, may be administered by the intravenous route to maximize their delivery to target tissues. Blood components, such as antibody, complement and blood cells (such as neutrophils, monocytes, T cells, B cells or platelets) may result in viral neutralization and ...
    Construction of Human Monocyte Derived Macrophages Armed with Oncolytic Viruses
    Authors:  Munitta Muthana, Jay Richardson, Samuel Rodrigues and Claire Lewis, date: 07/05/2013, view: 7322, Q&A: 0
    [Abstract] Macrophages are involved in many key physiological processes and complex responses such as inflammatory, immunological, infectious and neoplastic diseases. The appearance and activation of macrophages are thought to be rapid events in the development of many pathological lesions, including malignant tumours, atherosclerotic plaques, and arthritic ...



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