Molecular Biology


    Protocols in Current Issue
    Affymetrix Genome-wide Human SNP Assay
    Author:  Alexis Bosman, date: 05/20/2016, view: 6512, Q&A: 0
    [Abstract] To assess genomic variation, it is possible to identify the single nucleotide polymorphisms (SNP) which an individual carries. Using the Affymetrix Genome-wide Human SNP Assay, it is possible to assess 906,600 SNPs on a single array. This protocol, the next iteration of the GeneChip Mapping 500K array set, is based directly on the manufacturers’ ...
    Gene Networks Based on the Graphical Gaussian Model
    Author:  Shisong Ma, date: 02/20/2012, view: 13171, Q&A: 1
    [Abstract] This protocol describes how to build a gene network based on the graphical Gaussian model (GGM) from large scale microarray data. GGM uses partial correlation coefficient (pcor) to infer co-expression relationship between genes. Compared to the traditional Pearson’ correlation coefficient, partial correlation is a better measurement of direct ...

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