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Gene Expression Omnibus (GEO) data
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Microarray gene expression data of HCC patient's cohort was downloaded from the GEO database (accession numbers GSE1898).14 R package “GEOquery” was used to extract the expression values of genes of interests. Clinical data was accessed from the PRECOG (www.precog.stanford.edu/index.php). In this validation cohort, mRNA cutoffs that could divide patients into the same percentage as cutoffs in the TCGA set did were applied (OX40: -0.63; CD68: 0.78; CD8A: -1.19; LAG3: 0.20)
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